Glyph Technologies Knowledge Base

When booted into 32-bit mode, Glyph Manager will see a FireWire connected drive under 10.7 Lion
When booted into 64-bit mode, Glyph Manager will not see a FireWire connected drive under 10.7 Lion
When booted into 32 or 64-bit mode, Glyph Manager will see a USB connected drive under 10.6 or 10.7

The problem happens with 64-bit (either 10.6 or 10.7) and Glyph Manager working with a FireWire connected drive.
If you are using 64-bit, the workaround at this time is to connect via USB to change drive modes, then return back to FireWire.

More about booting 64-bit and 32-bit mode:
http://support.apple.com/kb/HT3770
http://support.apple.com/kb/ht3773